Neuroblastoma and Catecholamines

Excretion of catecholamines in relatives of patients with familial neuroblastoma.

The urinary excretion of catecholamines in 13 close relatives of two distantly related patients with congenital neuroblastoma was investigated. One of these relatives was a child with already known ganglioneuroblastoma. The catecholamines noradrenaline and dopamine were determined. Vanilmandelic acid and homovanillic acid also were determined and numerous other catecholamine metabolites were me...

How Reliable are Urine Catecholamines in the Workup of Neuroblastoma Associated with Opsoclonus Myoclonus Ataxia?

We report a rare case of neuroblastoma with Opsoclonus Myoclonus Ataxia (OMA) and Horner’s syndrome in a previously healthy 17-month-old female who presented with titubations and a wide based gait. The patient had an initial negative workup including urine catecholamines. After further investigation, including a Magnetic Resonance Imaging (MRI) of the spine, neuroblastoma was revealed. This cas...

Catecholamines and hypertension.

Ever since the demonstration that the active principle in the adrenal medulla can raise blood pressure (Oliver & Schafer, 1895), catecholamines have been implicated in the hypertensive diseases. The identity of noradrenaline as the neurotransmitter of sympathetic nerves (von Euler, 1946) and the demonstration that an injection of this catecholamine can produce cardiovascular changes similar to ...

Catecholamines and stress.

The subject of catecholamines and stress has occupied researchers for many years and filled many books. A brief revew such as this cannot cover such a broad topic. Instead, provided here are a few concepts, reflecting somewhat different viewpoints from those in standard textbooks. The first of these concepts is that there are three distinct peripheral catecholamine systems, each with different ...

Bone Involvement in Neuroblastoma